Many Distinct Ways Lead to Drug Resistance in <i>BRAF</i>- and <i>NRAS</i>-Mutated Melanomas

Many Distinct Ways Lead to Drug Resistance in <i>BRAF</i>- and <i>NRAS</i>-Mutated Melanomas

Advanced melanoma is a relentless tumor with a high metastatic potential. The combat of melanoma by using the targeted therapy is impeded because several major driver mutations fuel its growth (predominantly <i>BRAF</i> and <i>NRAS</i>). Both these mutated oncogenes strongly...

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Bibliographic Details
Main Authors: Jiri Vachtenheim, Lubica Ondrušová
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Life
Subjects:
melanoma
BRAF
NRAS
drug resistance
phenotype switching
Online Access:https://www.mdpi.com/2075-1729/11/5/424

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