Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex

Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex

The pathogenesis of Helicobacter pylori-associated gastric cancer is dependent on delivery of CagA into host cells through a type IV secretion system (T4SS). The H. pylori Cag T4SS includes a large membrane-spanning core complex containing five proteins, organized into an outer membrane cap (OMC), a...

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Bibliographic Details
Main Authors: Michael J Sheedlo, Jeong Min Chung, Neha Sawhney, Clarissa L Durie, Timothy L Cover, Melanie D Ohi, D Borden Lacy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
Helicobacter pylori
type iv secretion
molecular machine
cryo-electron microscopy
gastric cancer
bacterial protein secretion
Online Access:https://elifesciences.org/articles/59495

Internet

https://elifesciences.org/articles/59495

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