Quantifying impairment and disease severity using AI models trained on healthy subjects

Abstract Automatic assessment of impairment and disease severity is a key challenge in data-driven medicine. We propose a framework to address this challenge, which leverages AI models trained exclusively on healthy individuals. The COnfidence-Based chaRacterization of Anomalies (COBRA) score exploi...

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Bibliographic Details
Main Authors: Boyang Yu, Aakash Kaku, Kangning Liu, Avinash Parnandi, Emily Fokas, Anita Venkatesan, Natasha Pandit, Rajesh Ranganath, Heidi Schambra, Carlos Fernandez-Granda
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:npj Digital Medicine
Online Access:https://doi.org/10.1038/s41746-024-01173-x