Factors to Consider for the Correct Use of γH2AX in the Evaluation of DNA Double-Strand Breaks Damage Caused by Ionizing Radiation

Factors to Consider for the Correct Use of γH2AX in the Evaluation of DNA Double-Strand Breaks Damage Caused by Ionizing Radiation

People exposed to ionizing radiation (IR) both for diagnostic and therapeutic purposes is constantly increasing. Since the use of IR involves a risk of harmful effects, such as the DNA DSB induction, an accurate determination of this induced DNA damage and a correct evaluation of the risk–benefit ra...

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Bibliographic Details
Main Authors: Davide Valente, Maria Pia Gentileschi, Antonino Guerrisi, Vicente Bruzzaniti, Aldo Morrone, Silvia Soddu, Alessandra Verdina
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
DNA damage
double-strand breaks (DSBs)
DNA repair
γH2AX scoring
ionizing radiation
basal level
Online Access:https://www.mdpi.com/2072-6694/14/24/6204

Internet

https://www.mdpi.com/2072-6694/14/24/6204

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