Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors

Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors

The human fibroblast growth factor receptors (FGFRs) are attractive targets for cancer therapy, but the structural basis for kinase targeting and gatekeeper mutations of covalent FGFR inhibitors are not fully understood. Here the authors report and discuss the potency and selectivity of FGFR inhibit...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Lingzhi Qu, Xiaojuan Chen, Hudie Wei, Ming Guo, Shuyan Dai, Longying Jiang, Jun Li, Sitong Yue, Zhuchu Chen, Yongheng Chen
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Nature Portfolio 2022-01-01
Sraith:Communications Chemistry
Rochtain ar líne:https://doi.org/10.1038/s42004-021-00623-x

Ar líne

https://doi.org/10.1038/s42004-021-00623-x

Míreanna comhchosúla