Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease

Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease

Metabolic-associated fatty liver disease (MAFLD), which is previously known as non-alcoholic fatty liver disease (NAFLD), represents a major health concern worldwide with limited therapy. Here, we provide evidence that ferroptosis, a novel form of regulated cell death characterized by iron-driven li...

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Bibliographic Details
Main Authors: Jie Tong, Dongjie Li, Hongbo Meng, Diyang Sun, Xiuting Lan, Min Ni, Jiawei Ma, Feiyan Zeng, Sijia Sun, Jiangtao Fu, Guoqiang Li, Qingxin Ji, Guoyan Zhang, Qirui Shen, Yuanyuan Wang, Jiahui Zhu, Yi Zhao, Xujie Wang, Yi Liu, Shenxi Ouyang, Chunquan Sheng, Fuming Shen, Pei Wang
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ferroptosis
GPX4
Alternative isoform
Fatty liver
Oligomerization
Methionine/choline-deficient diet
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522000533

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http://www.sciencedirect.com/science/article/pii/S2211383522000533

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