Activation of the Large-Conductance, Voltage, and Ca2+- Activated K+ (BK) Channel in Acute Spinal Cord Injury in the Wistar Rat Is Neuroprotective

Activation of the Large-Conductance, Voltage, and Ca2+- Activated K+ (BK) Channel in Acute Spinal Cord Injury in the Wistar Rat Is Neuroprotective

Context/Objectives: Spinal cord injury (SCI) results in significant neuronal and glial cell death resulting in impaired neurological and motor function. Uncontrolled Ca2+ entry results in excitotoxicity and cell death. In this study, we examine the use of a BK channel activator, Isopimaric acid (ISO...

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Bibliographic Details
Main Authors: Marianne Jacobsen, Kristen Lett, John Mark Barden, Gavin L. Simpson, Josef Buttigieg
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Neurology
Subjects:
spinal cord injury
excitotoxicity
motor function
electrophysiology
immunohistochemistry
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.01107/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.01107/full

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