Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues

Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues

Abstract The endogenous cyclic tetradecapeptide SST14 was reported to stimulate all five somatostatin receptors (SSTR1–5) for hormone release, neurotransmission, cell growth arrest and cancer suppression. Two SST14-derived short cyclic SST analogues (lanreotide or octreotide) with improved stability...

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Bibliographic Details
Main Authors: Qing Bo, Fan Yang, Yingge Li, Xianyu Meng, Huanhuan Zhang, Yingxin Zhou, Shenglong Ling, Demeng Sun, Pei Lv, Lei Liu, Pan Shi, Changlin Tian
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00405-2

Internet

https://doi.org/10.1038/s41421-022-00405-2

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