Identification of the hybrid gene LILRB5-3 by long-read sequencing and implication of its novel signaling function

Leukocyte immunoglobulin (Ig)-like receptors (LILRs) on human chromosome 19q13.4 encode 11 immunoglobulin superfamily receptors, exhibiting genetic diversity within and between human populations. Among the LILR genes, the genomic region surrounding LILRB3 and LILRA6 has yet to be fully characterized...

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Main Authors: Kouyuki Hirayasu, Seik-Soon Khor, Yosuke Kawai, Mihoko Shimada, Yosuke Omae, Gen Hasegawa, Yuko Hashikawa, Hiromu Tanimoto, Jun Ohashi, Kazuyoshi Hosomichi, Atsushi Tajima, Hiroyuki Nakamura, Minoru Nakamura, Katsushi Tokunaga, Rikinari Hanayama, Masao Nagasaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1398935/full