Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling

Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling

Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk. Here we set out to examine the role of this pseudokinase in atherosclerotic plaque development. Human endarterectomy atherosclerotic tiss...

Full description

Bibliographic Details
Main Authors: Laura Martinez-Campesino, Klaudia Kocsy, Jaime Cañedo, Jessica M. Johnston, Charlotte E. Moss, Simon A. Johnston, Stephen Hamby, Alison H. Goodall, Jessica Redgrave, Sheila E. Francis, Endre Kiss-Toth, Heather L. Wilson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
atherosclerosis
TRIB3
macrophage
fibrous
cap
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.948461/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.948461/full

Similar Items