Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling

Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling

Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk. Here we set out to examine the role of this pseudokinase in atherosclerotic plaque development. Human endarterectomy atherosclerotic tiss...

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Hlavní autoři: Laura Martinez-Campesino, Klaudia Kocsy, Jaime Cañedo, Jessica M. Johnston, Charlotte E. Moss, Simon A. Johnston, Stephen Hamby, Alison H. Goodall, Jessica Redgrave, Sheila E. Francis, Endre Kiss-Toth, Heather L. Wilson
Médium: Článek
Jazyk:English
Vydáno: Frontiers Media S.A. 2022-08-01
Edice:Frontiers in Cardiovascular Medicine
Témata:
atherosclerosis
TRIB3
macrophage
fibrous
cap
On-line přístup:https://www.frontiersin.org/articles/10.3389/fcvm.2022.948461/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.948461/full

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