The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling

The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling

Abstract The leukocyte integrin LFA1 is indispensable for immune responses, orchestrating lymphocyte trafficking and adhesion. While LFA1 activation induces LFA1 clustering at the cell contact surface via outside-in signaling, the regulatory mechanisms remain unclear. Here, we uncovered a previously...

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Bibliográfalaš dieđut
Váldodahkkit: Naoyuki Kondo, Yuko Mimori-Kiyosue, Keizo Tokuhiro, Giuseppe Pezzotti, Tatsuo Kinashi
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Nature Portfolio 2025-02-01
Ráidu:Nature Communications
Liŋkkat:https://doi.org/10.1038/s41467-025-56631-1

Interneahtta

https://doi.org/10.1038/s41467-025-56631-1

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