S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma
Multiple myeloma (MM) is the second most prevalent hematologic malignancy and is incurable because of the inevitable development of drug resistance. Methionine adenosyltransferase 2α (MAT2A) is the primary producer of the methyl donor S-adenosylmethionine (SAM) and several studies have documented M...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ferrata Storti Foundation
2023-07-01
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| Series: | Haematologica |
| Online Access: | https://haematologica.org/article/view/11167 |