Structural and functional analysis of the small GTPase ARF1 reveals a pivotal role of its GTP-binding domain in controlling of the generation of viral inclusion bodies and replication of grass carp reovirus

Structural and functional analysis of the small GTPase ARF1 reveals a pivotal role of its GTP-binding domain in controlling of the generation of viral inclusion bodies and replication of grass carp reovirus

Grass carp reovirus (GCRV) is the most pathogenic double-stranded (ds) RNA virus among the isolated aquareoviruses. The molecular mechanisms by which GCRV utilizes host factors to generate its infectious compartments beneficial for viral replication and infection are poorly understood. Here, we disc...

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Bibliographic Details
Main Authors: Jie Zhang, Pengwei Li, Riye Lu, Songying Ouyang, Ming Xian Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
grass carp reovirus
viral inclusion bodies
nonstructural proteins NS80 and NS38
ADP ribosylation factor 1
gcARF1-GDP complex
GTPase activity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.956587/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.956587/full

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