Induction of Survival of Motor Neuron (SMN) Protein Deficiency in Spinal Astrocytes by Small Interfering RNA as an In Vitro Model of Spinal Muscular Atrophy

Induction of Survival of Motor Neuron (SMN) Protein Deficiency in Spinal Astrocytes by Small Interfering RNA as an In Vitro Model of Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a motor neuron disorder leading to progressive loss of ventral horn neurons resulting in muscle wasting. Here we investigate the contribution of spinal astrocytes to the pathogenesis of late-onset SMA forms using a mouse model. Furthermore, we generated SMA-like astr...

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Bibliographic Details
Main Authors: Markus Leo, Linda-Isabell Schmitt, Michael Fleischer, Rebecca Steffen, Cora Osswald, Christoph Kleinschnitz, Tim Hagenacker
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
spinal muscular atrophy
SMA
survival of motor neuron
SMN
siRNA
astrocytes
Online Access:https://www.mdpi.com/2073-4409/11/3/558

Internet

https://www.mdpi.com/2073-4409/11/3/558

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