Insulin Diminishes Superoxide Increase in Cytosol and Mitochondria of Cultured Cortical Neurons Treated with Toxic Glutamate

Insulin Diminishes Superoxide Increase in Cytosol and Mitochondria of Cultured Cortical Neurons Treated with Toxic Glutamate

Glutamate excitotoxicity is involved in the pathogenesis of many disorders, including stroke, traumatic brain injury, and Alzheimer’s disease, for which central insulin resistance is a comorbid condition. Neurotoxicity of glutamate (Glu) is primarily associated with hyperactivation of the ionotropic...

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Bibliographic Details
Main Authors: Vsevolod Pinelis, Irina Krasilnikova, Zanda Bakaeva, Alexander Surin, Dmitrii Boyarkin, Andrei Fisenko, Olga Krasilnikova, Igor Pomytkin
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
insulin
glutamate (Glu) excitotoxicity
intracellular free Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>)
intracellular superoxide (O<sub>2</sub><sup>–•</sup>)
mitochondrial superoxide production
primary cortical neurons
Online Access:https://www.mdpi.com/1422-0067/23/20/12593

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https://www.mdpi.com/1422-0067/23/20/12593

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