LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans

LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans

Summary: Insulin-mechanistic target of rapamycin (mTOR) signaling drives anabolic growth during organismal development; its late-life dysregulation contributes to aging and limits lifespans. Age-related regulatory mechanisms and functional consequences of insulin-mTOR remain incompletely understood....

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Bibliographic Details
Main Authors: Taruna Pandey, Bingying Wang, Changnan Wang, Jenny Zu, Huichao Deng, Kang Shen, Goncalo Dias do Vale, Jeffrey G. McDonald, Dengke K. Ma
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Metabolism
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724002274

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http://www.sciencedirect.com/science/article/pii/S2211124724002274

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