An engineered protein-based submicromolar competitive inhibitor of the Staphylococcus aureus virulence factor aureolysin

An engineered protein-based submicromolar competitive inhibitor of the Staphylococcus aureus virulence factor aureolysin

Aureolysin, a secreted metallopeptidase (MP) from the thermolysin family, functions as a major virulence factor in Staphylococcus aureus. No specific aureolysin inhibitors have yet been described, making this an important target for the development of novel antimicrobial drugs in times of rampant an...

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Bibliographic Details
Main Authors: Soraia R. Mendes, Ulrich Eckhard, Arturo Rodríguez-Banqueri, Tibisay Guevara, Peter Czermak, Enrique Marcos, Andreas Vilcinskas, F. Xavier Gomis-Rüth
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Bacterial infection
Metallopeptidase
Protein inhibitor
Protein design
Therapeutic protein
Crystal structure
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022000022

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http://www.sciencedirect.com/science/article/pii/S2001037022000022

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