Exome-Wide Meta-Analysis Identifies Rare 3′-UTR Variant in ERCC1/CD3EAP Associated with Symptoms of Sleep Apnea

Exome-Wide Meta-Analysis Identifies Rare 3′-UTR Variant in ERCC1/CD3EAP Associated with Symptoms of Sleep Apnea

Obstructive sleep apnea (OSA) is a common sleep breathing disorder associated with an increased risk of cardiovascular and cerebrovascular diseases and mortality. Although OSA is fairly heritable (~40%), there have been only few studies looking into the genetics of OSA. In the present study, we aime...

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Bibliographic Details
Main Authors: Ashley van der Spek, Annemarie I. Luik, Desana Kocevska, Chunyu Liu, Rutger W. W. Brouwer, Jeroen G. J. van Rooij, Mirjam C. G. N. van den Hout, Robert Kraaij, Albert Hofman, André G. Uitterlinden, Wilfred F. J. van IJcken, Daniel J. Gottlieb, Henning Tiemeier, Cornelia M. van Duijn, Najaf Amin
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Genetics
Subjects:
sleep apnea syndromes
sleep
genetics
exome
sequence analysis
ERCC1
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2017.00151/full

Internet

http://journal.frontiersin.org/article/10.3389/fgene.2017.00151/full

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