Addition of polygenic risk score to a risk calculator for prediction of breast cancer in US Black women

Addition of polygenic risk score to a risk calculator for prediction of breast cancer in US Black women

Abstract Background Previous work in European ancestry populations has shown that adding a polygenic risk score (PRS) to breast cancer risk prediction models based on epidemiologic factors results in better discriminatory performance as measured by the AUC (area under the curve). Following publicati...

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Bibliographic Details
Main Authors: Gary R. Zirpoli, Ruth M. Pfeiffer, Kimberly A. Bertrand, Dezheng Huo, Kathryn L. Lunetta, Julie R. Palmer
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Breast Cancer Research
Subjects:
Risk prediction
Breast cancer
African American
Polygenic risk score
Online Access:https://doi.org/10.1186/s13058-023-01748-8

Internet

https://doi.org/10.1186/s13058-023-01748-8

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