Microglial amyloid beta clearance is driven by PIEZO1 channels

Microglial amyloid beta clearance is driven by PIEZO1 channels

Abstract Background Microglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's disease (AD), toxic amyloid beta (Aβ) accumulates in the brain and forms stiff plaques. In late-onset AD accou...

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Main Authors: Henna Jäntti, Valeriia Sitnikova, Yevheniia Ishchenko, Anastasia Shakirzyanova, Luca Giudice, Irene F. Ugidos, Mireia Gómez-Budia, Nea Korvenlaita, Sohvi Ohtonen, Irina Belaya, Feroze Fazaludeen, Nikita Mikhailov, Maria Gotkiewicz, Kirsi Ketola, Šárka Lehtonen, Jari Koistinaho, Katja M. Kanninen, Damian Hernández, Alice Pébay, Rosalba Giugno, Paula Korhonen, Rashid Giniatullin, Tarja Malm
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Neuroinflammation
Subjects:
Piezo1
Mechanoreceptor
Alzheimer’s disease
iPSC-derived microglia
iMGL
Amyloid
Online Access:https://doi.org/10.1186/s12974-022-02486-y

Internet

https://doi.org/10.1186/s12974-022-02486-y

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