The biomarker HE4 (WFDC2) promotes a pro-angiogenic and immunosuppressive tumor microenvironment via regulation of STAT3 target genes

The biomarker HE4 (WFDC2) promotes a pro-angiogenic and immunosuppressive tumor microenvironment via regulation of STAT3 target genes

Abstract Epithelial ovarian cancer (EOC) is a highly lethal gynecologic malignancy arising from the fallopian tubes that has a high rate of chemoresistant recurrence and low five-year survival rate. The ovarian cancer biomarker HE4 is known to promote proliferation, metastasis, chemoresistance, and...

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Bibliographic Details
Main Authors: Nicole E. James, Jenna B. Emerson, Ashley D. Borgstadt, Lindsey Beffa, Matthew T. Oliver, Virginia Hovanesian, Anze Urh, Rakesh K. Singh, Rachael Rowswell-Turner, Paul A. DiSilvestro, Joyce Ou, Richard G. Moore, Jennifer R. Ribeiro
Format: Article
Language:English
Published: Nature Portfolio 2020-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-65353-x

Internet

https://doi.org/10.1038/s41598-020-65353-x

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