Targeting Chondroitin Sulphate Synthase 1 (Chsy1) Promotes Axon Growth Following Neurorrhaphy by Suppressing Versican Accumulation

Targeting Chondroitin Sulphate Synthase 1 (Chsy1) Promotes Axon Growth Following Neurorrhaphy by Suppressing Versican Accumulation

Versican is a chondroitin sulfate proteoglycan (CSPG), which deposits in perineurium as a physical barrier and prevents the growth of axons out of the fascial boundary. Several studies have indicated that the chondroitin sulfate (CS) chains on versican have several possible functions beyond the phys...

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Bibliographic Details
Main Authors: Chiung-Hui Liu, Ying-Jui Ho, Che-Yu Wang, Chao-Chun Hsu, Yin-Hung Chu, Min-Yen Hsu, Shiu-Jau Chen, Wen-Chuan Hsiao, Wen-Chieh Liao
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
Chsy1
versican
nerve regeneration
end-to-side neurorrhaphy
peripheral nerve injury
Schwann cells
Online Access:https://www.mdpi.com/1420-3049/28/9/3742

Internet

https://www.mdpi.com/1420-3049/28/9/3742

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