Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

Antioxidant systems, such as the thioredoxin-1 (Trx1) pathway, ensure cellular redox homeostasis. However, how such systems regulate development and function of myeloid cells is barely understood. Here we show that in contrast to its critical role in T cells, the murine Trx1 system is dispensable fo...

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Bibliographic Details
Main Authors: Jonathan Muri, Helen Thut, Qian Feng, Manfred Kopf
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
nf- kb
NLRP3 inflammasome
thioredoxin-1
glutaredoxin
reactive oxygen species
txnip
Online Access:https://elifesciences.org/articles/53627

Internet

https://elifesciences.org/articles/53627

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