Role of endothelin-1 antagonist; bosentan, against cisplatin-induced nephrotoxicity in male and female rats

Role of endothelin-1 antagonist; bosentan, against cisplatin-induced nephrotoxicity in male and female rats

Background: Cisplatin (CP) is a chemotherapy drug, with the major side effect of nephrotoxicity. The level of endothelin-1 (ET-1) increases during nephrotoxicity, which is accompanied with vasoconstrictive properties. Bosentan (BOS) is a nonselective ET-1 receptor antagonist, having vasodilatory and...

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Bibliographic Details
Main Authors: Zahra Jokar, Mehdi Nematbakhsh, Maryam Moeini, Ardeshir Talebi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Advanced Biomedical Research
Subjects:
Bosentan
cisplatin
gender
nephrotoxicity
rat
Online Access:http://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=83;epage=83;aulast=Jokar

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http://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=83;epage=83;aulast=Jokar

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