Hippocampal versus cortical deletion of cholinergic receptor muscarinic 1 in mice differentially affects post-translational modifications and supramolecular assembly of respiratory chain-associated proteins, mitochondrial ultrastructure, and respiration: implications in Alzheimer’s disease

Hippocampal versus cortical deletion of cholinergic receptor muscarinic 1 in mice differentially affects post-translational modifications and supramolecular assembly of respiratory chain-associated proteins, mitochondrial ultrastructure, and respiration: implications in Alzheimer’s disease

Introduction: In a previous retrospective study using postmortem human brain tissues, we demonstrated that loss of Cholinergic Receptor Muscarinic 1 (CHRM1) in the temporal cortex of a subset of Alzheimer’s patients was associated with poor survival, whereas similar loss in the hippocampus showed no...

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Bibliographic Details
Main Authors: Mohammad Golam Sabbir, Mamiko Swanson, Robert C. Speth, Benedict C. Albensi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
muscarinic acetylcholine type 1 receptor CHRM1
hippocampus
cerebral cortex
mitochondria
respiratory complex assembly
respiration
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1179252/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1179252/full

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