Dietary Conjugated Linoleic Acid Modulates the Hepatic Circadian Clock Program via PPARα/REV-ERBα-Mediated Chromatin Modification in Mice

Dietary Conjugated Linoleic Acid Modulates the Hepatic Circadian Clock Program via PPARα/REV-ERBα-Mediated Chromatin Modification in Mice

Scope: Disruptions of circadian rhythm cause metabolic disorders and are closely related to dietary factors. In this study, we investigated the interplays between the dietary conjugated linoleic acid (CLA)-induced hepatic steatosis and the circadian clock regulation, in association with lipid homeos...

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Bibliographic Details
Main Authors: Hao-Yu Liu, Haotian Gu, Yanwei Li, Ping Hu, Yatian Yang, Kaiqi Li, Hao Li, Kexin Zhang, Bo Zhou, Huaxing Wu, Wenbin Bao, Demin Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Nutrition
Subjects:
circadian clock
metabolic physiology
nuclear receptor
PPARα
REV-ERBα
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2021.711398/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2021.711398/full

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