Modulating the microenvironment during FVIII uptake influences the nature of FVIII-peptides presented by antigen-presenting cells

Modulating the microenvironment during FVIII uptake influences the nature of FVIII-peptides presented by antigen-presenting cells

Background and aimsHemophilia A is a severe bleeding disorder caused by the deficiency of functionally active coagulation factor VIII (FVIII). The induction of neutralizing anti-drug antibodies is a major complication in the treatment of hemophilia A patients with FVIII replacement therapies. Why so...

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Bibliographic Details
Main Authors: Christian Lubich, Katharina Nora Steinitz, Brigitte Hoelbl, Thomas Prenninger, Pauline Maria van Helden, Markus Weiller, Birgit Maria Reipert
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
FVIII presentation by antigen-presenting cells
FVIII-specific CD4+ T-cell hybridoma library
HLA-DRB1*1501 humanized hemophilic mice
Hemophilia A
neutralizing anti-drug antibodies
FVIII inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.975680/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.975680/full

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