Acceleration of Protein Degradation by 20S Proteasome-Binding Peptides Generated by In Vitro Artificial Evolution

Acceleration of Protein Degradation by 20S Proteasome-Binding Peptides Generated by In Vitro Artificial Evolution

Although the 20S core particle (CP) of the proteasome is an important component of the 26S holoenzyme, the stand-alone 20S CP acts directly on intrinsically disordered and oxidized/damaged proteins to degrade them in a ubiquitin-independent manner. It has been postulated that some structural feature...

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Bibliographic Details
Main Authors: Yunhao Zhu, Kaishin Shigeyoshi, Yumiko Hayakawa, Sae Fujiwara, Masamichi Kishida, Hitoshi Ohki, Tomohisa Horibe, Masafumi Shionyu, Tamio Mizukami, Makoto Hasegawa
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
directed evolution
peptides
photoaffinity labeling
proteasome
protein degradation
Online Access:https://www.mdpi.com/1422-0067/24/24/17486

Internet

https://www.mdpi.com/1422-0067/24/24/17486

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