Salmonella actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner

Salmonella actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner

ABSTRACT The transcription factor TFEB drives the expression of lysosomal, autophagic, and immune-responsive genes in response to LPS and phagocytosis. Interestingly, compounds that promote TFEB activity enhance bactericidal activity, while intracellular pathogens like Mycobacterium and Salmonella r...

Full description

Bibliographic Details
Main Authors: Subothan Inpanathan, Erika Ospina-Escobar, Vanessa Cruz Li, Zainab Adamji, Tracy Lackraj, Youn Hee Cho, Natasha Porco, Christopher H. Choy, Joseph B. McPhee, Roberto J. Botelho
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:Microbiology Spectrum
Subjects:
bacteria
macrophages
transcription factors
cell adaptation
innate immunity
Salmonella
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04981-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.04981-22

Similar Items