Salmonella actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner

Salmonella actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner

ABSTRACT The transcription factor TFEB drives the expression of lysosomal, autophagic, and immune-responsive genes in response to LPS and phagocytosis. Interestingly, compounds that promote TFEB activity enhance bactericidal activity, while intracellular pathogens like Mycobacterium and Salmonella r...

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Bibliographic Details
Main Authors: Subothan Inpanathan, Erika Ospina-Escobar, Vanessa Cruz Li, Zainab Adamji, Tracy Lackraj, Youn Hee Cho, Natasha Porco, Christopher H. Choy, Joseph B. McPhee, Roberto J. Botelho
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:Microbiology Spectrum
Subjects:
bacteria
macrophages
transcription factors
cell adaptation
innate immunity
Salmonella
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04981-22

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