Acute ischemia induces spatially and transcriptionally distinct microglial subclusters

Acute ischemia induces spatially and transcriptionally distinct microglial subclusters

Abstract Background Damage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult and initiate immune inflammation, playing an important role in the cellular injury after stroke. However, the microglial heterogeneity and the mechani...

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Bibliographic Details
Main Authors: Huiya Li, Pinyi Liu, Bing Zhang, Zengqiang Yuan, Mengdi Guo, Xinxin Zou, Yi Qian, Shiji Deng, Liwen Zhu, Xiang Cao, Tao Tao, Shengnan Xia, Xinyu Bao, Yun Xu
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Genome Medicine
Subjects:
Ischemic stroke
Microglia
scRNA-seq
Spatial transcriptomics
BACH1
Glucocorticoids
Online Access:https://doi.org/10.1186/s13073-023-01257-5

Internet

https://doi.org/10.1186/s13073-023-01257-5

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