Synthesis of Bicyclo-DNA Nucleosides with Additional Functionalization in the Carbocyclic Ring

Two novel bicyclo nucleoside isomers carrying the base thymine in the furanose ring and an ester substituent in the carbocyclic ring were synthesized from a common bicyclic sugar precursor via a cyclopropanation/fragmentation pathway in nine steps. The relative configuration of the ester s...

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Bibliographic Details
Main Authors: Samuel Luisier, Christian J. Leumann
Format: Article
Language:deu
Published: Swiss Chemical Society 2008-04-01
Series:CHIMIA
Subjects:
Online Access:https://chimia.ch/chimia/article/view/4477