Oncolytic adenovirus-mediated expression of decorin facilitates CAIX-targeting CAR-T therapy against renal cell carcinoma

Oncolytic adenovirus-mediated expression of decorin facilitates CAIX-targeting CAR-T therapy against renal cell carcinoma

Although chimeric antigen receptor T cell (CAR-T) therapy has been successful for hematological malignancies, it is less effective for solid tumors. The primary reason is that the immune microenvironment restricts CAR-T cells from infiltrating and proliferating in tumors. Oncolytic virotherapy has e...

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Bibliographic Details
Main Authors: Chen Zhang, Lin Fang, Xueyan Wang, Sen Yuan, Wanjing Li, Weiping Tian, Jing Chen, Qi Zhang, Yuxin Zhang, Qing Zhang, Junnian Zheng
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic adenovirus
chimeric antigen receptor T cell
Decorin
carbonic anhydrase IX
renal cell carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001674

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http://www.sciencedirect.com/science/article/pii/S2372770521001674

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