Generation, characterization, and validation of two human induced pluripotent stem cell lines from the peripheral blood of young and older adults

Aging is a leading risk factor for the development of age-related diseases. However, how aging impacts human induced pluripotent stem cell (hiPSC) reprogramming, age-related epigenetic memory post-reprogramming, differentiation, and its potential applicability to cardiovascular regenerative medicine...

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Bibliographic Details
Main Authors: Dongli Yang, Jun Chen, Jerry H. Juratli, Andre Monteiro da Rocha, Allison Schley, Nadia R. Sutton
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Stem Cell Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506125000200