Oral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice

Oral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice

Abstract Background The R1441G mutation in the leucine-rich repeat kinase 2 (LRRK2) gene results in late-onset Parkinson’s disease (PD). Peripheral inflammation and gut microbiota are closely associated with the pathogenesis of PD. Chronic periodontitis is a common type of peripheral inflammation, w...

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Bibliographic Details
Main Authors: Yu-Kun Feng, Qiong-Li Wu, Yan-Wen Peng, Feng-Yin Liang, Hua-Jing You, Yi-Wei Feng, Ge Li, Xue-Jiao Li, Shu-Hua Liu, Yong-Chao Li, Yu Zhang, Zhong Pei
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Neuroinflammation
Subjects:
Chronic periodontitis
Parkinson’s disease
Dopaminergic neurons
R1441G LRRK2
IL-17A
Online Access:http://link.springer.com/article/10.1186/s12974-020-02027-5

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http://link.springer.com/article/10.1186/s12974-020-02027-5

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