The two faces of synaptic failure in App NL-G-F knock-in mice

The two faces of synaptic failure in App NL-G-F knock-in mice

Abstract Background Intensive basic and preclinical research into Alzheimer’s disease (AD) has yielded important new findings, but they could not yet been translated into effective therapies. One of the reasons is the lack of animal models that sufficiently reproduce the complexity of human AD and t...

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Bibliographic Details
Main Authors: Amira Latif-Hernandez, Victor Sabanov, Tariq Ahmed, Katleen Craessaerts, Takashi Saito, Takaomi Saido, Detlef Balschun
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
App knock-in mice
Long-term potentiation
Long-term depression
Miniature synaptic currents
Presynaptic glutamatergic and GABAergic upregulation
Electrophysiological phenotyping
Online Access:http://link.springer.com/article/10.1186/s13195-020-00667-6

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http://link.springer.com/article/10.1186/s13195-020-00667-6

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