Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states.

Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states.

Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM) loci in budding yeast. We have performed a detailed biochemical and genetic analysis of the largest Sir protein, Sir4. The N-...

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Bibliographic Details
Main Authors: Stephanie Kueng, Monika Tsai-Pflugfelder, Mariano Oppikofer, Helder C Ferreira, Emma Roberts, Chinyen Tsai, Tim-Christoph Roloff, Ragna Sack, Susan M Gasser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3359979?pdf=render

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http://europepmc.org/articles/PMC3359979?pdf=render

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