Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke.

Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke.

Given small sample sizes, loss of animals in preclinical experiments can dramatically alter results. However, effects of attrition on distortion of results are unknown. We used a simulation study to analyze the effects of random and biased attrition. As expected, random loss of samples decreased sta...

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Bibliographic Details
Main Authors: Constance Holman, Sophie K Piper, Ulrike Grittner, Andreas Antonios Diamantaras, Jonathan Kimmelman, Bob Siegerink, Ulrich Dirnagl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4699644?pdf=render

Internet

http://europepmc.org/articles/PMC4699644?pdf=render

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