Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function

Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function

The present work was done to elucidate whether hemichannels of a cell line derived from endothelial cells are affected by pro-inflammatory conditions (high glucose and IL-1β/TNF-α) known to lead to vascular dysfunction. We used EAhy 926 cells treated with high glucose and IL-1β/TNF-α. The hemichanne...

Full description

Bibliographic Details
Main Authors: Juan C. Sáez, Susana Contreras-Duarte, Gonzalo I. Gómez, Valeria C. Labra, Cristian A. Santibañez, Rosario Gajardo-Gómez, Beatriz C. Avendaño, Esteban F. Díaz, Trinidad D. Montero, Victoria Velarde, Juan A. Orellana
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
connexins
endothelium
inflammation
cytokines
gap junctions
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01899/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01899/full

Similar Items