Multi-Design Differential Expression Profiling of COVID-19 Lung Autopsy Specimens Reveals Significantly Deregulated Inflammatory Pathways and SFTPC Impaired Transcription

Multi-Design Differential Expression Profiling of COVID-19 Lung Autopsy Specimens Reveals Significantly Deregulated Inflammatory Pathways and SFTPC Impaired Transcription

The transcriptomic profiling of lung damage associated with SARS-CoV-2 infection may lead to the development of effective therapies to prevent COVID-19-related deaths. We selected a series of 21 autoptic lung samples, 14 of which had positive nasopharyngeal swabs for SARS-CoV-2 and a clinical diagno...

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Bibliographic Details
Main Authors: Matteo Fassan, Antonio Collesei, Valentina Angerilli, Marta Sbaraglia, Francesco Fortarezza, Federica Pezzuto, Monica De Gaspari, Gianluca Businello, Margherita Moni, Stefania Rizzo, Giulia Traverso, Veronica Colosso, Elisa Taschin, Francesca Lunardi, Aida Freire Valls, Francesca Schiavi, Cristina Basso, Fiorella Calabrese, Angelo Paolo Dei Tos
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
SARS-CoV-2
COVID-19
autopsy
transcriptomic profiling
inflammation
complement
Online Access:https://www.mdpi.com/2073-4409/11/6/1011

Internet

https://www.mdpi.com/2073-4409/11/6/1011

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