Dietary docosahexaenoic acid supplementation inhibits acute pulmonary transcriptional and autoantibody responses to a single crystalline silica exposure in lupus-prone mice

Dietary docosahexaenoic acid supplementation inhibits acute pulmonary transcriptional and autoantibody responses to a single crystalline silica exposure in lupus-prone mice

IntroductionWorkplace exposure to respirable crystalline silica (cSiO2) has been epidemiologically linked to lupus. Consistent with this, repeated subchronic intranasal cSiO2 instillation in lupus-prone NZBWF1 mice induces inflammation-/autoimmune-related gene expression, ectopic lymphoid tissue (EL...

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Bibliographic Details
Main Authors: Preeti S. Chauhan, Abby D. Benninghoff, Olivia K. Favor, James G. Wagner, Ryan P. Lewandowski, Lichchavi D. Rajasinghe, Quan-Zhen Li, Jack R. Harkema, James J. Pestka
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
crystalline silica
omega-3 fatty acid
docosahexaenoic acid (DHA)
inflammation
autoantibody
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1275265/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1275265/full

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