Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems
SUMMARY Nonsense mutations that result in the expression of truncated, N-terminal, fragments of the adenomatous polyposis coli (APC) tumour suppressor protein are found in most sporadic and some hereditary colorectal cancers. These mutations can cause tumorigenesis by eliminating β-catenin-binding s...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Company of Biologists
2012-11-01
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| Series: | Disease Models & Mechanisms |
| Online Access: | http://dmm.biologists.org/content/5/6/940 |