Nicotine acts on growth plate chondrocytes to delay skeletal growth through the alpha7 neuronal nicotinic acetylcholine receptor.

Nicotine acts on growth plate chondrocytes to delay skeletal growth through the alpha7 neuronal nicotinic acetylcholine receptor.

BACKGROUND: Cigarette smoking adversely affects endochondral ossification during the course of skeletal growth. Among a plethora of cigarette chemicals, nicotine is one of the primary candidate compounds responsible for the cause of smoking-induced delayed skeletal growth. However, the possible mech...

Full description

Bibliographic Details
Main Authors: Atsuo Kawakita, Kazuki Sato, Hatsune Makino, Hiroyasu Ikegami, Shinichiro Takayama, Yoshiaki Toyama, Akihiro Umezawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2596484?pdf=render

Internet

http://europepmc.org/articles/PMC2596484?pdf=render

Similar Items