Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria

Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria

Introduction: Primary hyperoxaluria (PH) is a family of 3 rare genetic disorders of hepatic glyoxylate metabolism that lead to overproduction and increased renal excretion of oxalate resulting in progressive renal damage. LDHA inhibition of glyoxylate-to-oxalate conversion by RNA interference (RNAi)...

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Bibliographic Details
Main Authors: Gema Ariceta, Kelly Barrios, Bob D. Brown, Bernd Hoppe, Ralf Rosskamp, Craig B. Langman
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Kidney International Reports
Subjects:
lactate dehydrogenase A
nedosiran
primary hyperoxaluria
RNA interference
small interfering RNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024921000322

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http://www.sciencedirect.com/science/article/pii/S2468024921000322

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