Advances in the use of PARP inhibitor therapy for breast cancer
Poly-ADP-ribose polymerase 1 (PARP-1) and PARP-2 are DNA damage sensors that are most active during S-phase of the cell cycle and that have wider-reaching roles in DNA repair than originally described. BRCA1 and BRCA2 (Breast Cancer) proteins are involved in homologous recombination repair (HRR), wh...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BioExcel Publishing Ltd
2018-08-01
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| Series: | Drugs in Context |
| Subjects: | |
| Online Access: | https://www.drugsincontext.com/advances-in-the-use-of-parp-inhibitor-therapy-for-breast-cancer |