Estrogen inhibits renal Na-Pi Co-transporters and improves klotho deficiency-induced acute heart failure

Estrogen inhibits renal Na-Pi Co-transporters and improves klotho deficiency-induced acute heart failure

Objective and hypothesis: Klotho is an aging-suppressor gene. Mutation of Klotho gene causes hyperphosphatemia and acute heart failure. However, the relationship of hyperphosphatemia and acute heart failure is unclear. We hypothesize that hyperphosphatemia mediates Klotho deficiency-induced acute he...

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Bibliographic Details
Main Authors: Kai Chen, Zhongjie Sun
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Redox Biology
Subjects:
Hyperphosphatemia
Na-pi co-transporter
heart failure
Estrogen
Oxidative stress
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721003335

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http://www.sciencedirect.com/science/article/pii/S2213231721003335

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