SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome

SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome

Abstract Hutchinson–Gilford progeria syndrome (HGPS) is a rare, fatal disease caused by Lamin A mutation, leading to altered nuclear architecture, loss of peripheral heterochromatin and deregulated gene expression. HGPS patients eventually die by coronary artery disease and cardiovascular alteration...

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Bibliographic Details
Main Authors: Giorgia Catarinella, Chiara Nicoletti, Andrea Bracaglia, Paola Procopio, Illari Salvatori, Marilena Taggi, Cristiana Valle, Alberto Ferri, Rita Canipari, Pier Lorenzo Puri, Lucia Latella
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05168-y

Internet

https://doi.org/10.1038/s41419-022-05168-y

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