Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trialResearch in context

Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trialResearch in context

Summary: Background: Inhaled molecular hydrogen gas (H2) has been shown to improve outcomes in animal models of cardiac arrest (CA). H2 inhalation is safe and feasible in patients after CA. We investigated whether inhaled H2 would improve outcomes after out-of-hospital CA (OHCA). Methods: HYBRID II...

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Bibliographic Details
Main Authors: Tomoyoshi Tamura, Masaru Suzuki, Koichiro Homma, Motoaki Sano, Ryoji Iizuka, Hiromichi Narimiya, Ryosuke Tsuruta, Kotaro Kaneda, Motoki Fujita, Junichi Sasaki, Osamu Akasaka, Keisuke Sawai, Makiko Nozaki, Hiroshi Imai, Ken Ishikura, Kaoru Ikejiri, Yasuyuki Kakihana, Shuhei Niiyama, Takahiro Futatsuki, Masahiro Honda, Yasuhiro Ikeda, Hideo Oka, Hideaki Yoshihara, Hirokazu Onishi, Susumu Yamashita, Koki Shimizu, Toshihiro Sakurai, Shu Yamada, Hiroshi Fukami, Nobuaki Shime, Kei Suzuki, Yasuhiro Kuroda, Kenya Kawakita, Akio Kimura, Tatsuki Uemura, Kiyotsugu Takuma, Kunio Kanao, Youichi Yanagawa, Ikuto Takeuchi
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:EClinicalMedicine
Subjects:
Out-of-hospital cardiac arrest
Hydrogen inhalation
Coma
Reperfusion injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537023000846

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http://www.sciencedirect.com/science/article/pii/S2589537023000846

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