α-Bisabolol Attenuates NF-κB/MAPK Signaling Activation and ER-Stress-Mediated Apoptosis by Invoking Nrf2-Mediated Antioxidant Defense Systems against Doxorubicin-Induced Testicular Toxicity in Rats

α-Bisabolol Attenuates NF-κB/MAPK Signaling Activation and ER-Stress-Mediated Apoptosis by Invoking Nrf2-Mediated Antioxidant Defense Systems against Doxorubicin-Induced Testicular Toxicity in Rats

The present study investigated the effects of α-bisabolol on DOX-induced testicular damage in rats. Testicular damage was induced in rats by injecting DOX (12.5 mg/kg, i.p., single dose) into rats. α-Bisabolol (25 mg/kg, i.p.) was administered to the rats along with DOX pre- and co-treatment daily f...

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Bibliographic Details
Main Authors: Seenipandi Arunachalam, Mohamed Fizur Nagoor Meeran, Sheikh Azimullah, Niraj Kumar Jha, Dhanya Saraswathiamma, Alia Albawardi, Rami Beiram, Shreesh Ojha
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Nutrients
Subjects:
α-bisabolol
doxorubicin
testicular dysfunction
NF-κB/MAPK signaling
ER stress
apoptosis
Online Access:https://www.mdpi.com/2072-6643/14/21/4648

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https://www.mdpi.com/2072-6643/14/21/4648

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